The most common systemic autoimmune diseases are systemic lupus erythematosus, Sjögren’s syndrome, myositis, scleroderma, vasculitis. These symptoms and the tests required can be very diverse. During the first consultation, after a detailed examination of the medical history and symptoms and complaints, blood sampling or consultation with other professions (cardiology, pulmonology, angiology, ophthalmology, nephrology, etc.) is required to establish the diagnosis and set the therapy.